Automated root cause analysis of performance problems in modern cloud computing infrastructures is of a high technology value in the self-driving context. Those systems are evolved into large scale and complex solutions which are core for running most of today’s business applications. Hence, cloud management providers realize their mission through a “total” monitoring of data center flows thus enabling a full visibility into the cloud. Appropriate machine learning methods and software products rely on such observation data for real-time identification and remediation of potential sources of performance degradations in cloud operations to minimize their impacts. We describe the existing technology challenges and our experiences while working on designing problem root cause analysis mechanisms which are automatic, application agnostic, and, at the same time, interpretable for human operators to gain their trust. The paper focuses on diagnosis of cloud ecosystems through their Key Performance Indicators (KPI). Those indicators are utilized to build automatically labeled data sets and train explainable AI models for identifying conditions and processes “responsible” for misbehaviors. Our experiments on a large time series data set from a cloud application demonstrate that those approaches are effective in obtaining models that explain unacceptable KPI behaviors and localize sources of issues.