Microarray technology is widely used to report gene expression data. The inclusion of many features and few samples is one of the characteristic features of this platform. In order to define significant genes for a particular disease, the problem of high-dimensionality microarray data should be overcome. The Artificial Bee Colony (ABC) Algorithm is a successful meta-heuristic algorithm that solves optimization problems effectively. In this paper, we propose a hybrid gene selection method for discriminatively selecting genes. We propose a new probabilistic binary Artificial Bee Colony Algorithm, namely PrBABC, that is hybridized with three different filter methods. The proposed method is applied to nine microarray datasets in order to detect distinctive genes for classifying cancer data. Results are compared with other wellknown meta-heuristic algorithms: Binary Differential Evolution Algorithm (BinDE), Binary Particle Swarm Optimization Algorithm (BinPSO), and Genetic Algorithm (GA), as well as with other methods in the literature. Experimental results show that the probabilistic self-adaptive learning strategy integrated into the employed-bee phase can boost classification accuracy with a minimal number of genes.