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  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher-id">109</journal-id>
      <journal-id journal-id-type="index">urn:lsid:arphahub.com:pub:3dc5f44e-8666-58db-bc76-a455210e8891</journal-id>
      <journal-title-group>
        <journal-title xml:lang="en">JUCS - Journal of Universal Computer Science</journal-title>
        <abbrev-journal-title xml:lang="en">jucs</abbrev-journal-title>
      </journal-title-group>
      <issn pub-type="ppub">0948-695X</issn>
      <issn pub-type="epub">0948-6968</issn>
      <publisher>
        <publisher-name>Journal of Universal Computer Science</publisher-name>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="doi">10.3217/jucs-002-02-0058</article-id>
      <article-id pub-id-type="publisher-id">27210</article-id>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Research Article</subject>
        </subj-group>
        <subj-group subj-group-type="scientific_subject">
          <subject>G.1.1 - Interpolation</subject>
          <subject>G.1.2 - Approximation</subject>
          <subject>G.4 - MATHEMATICAL SOFTWARE</subject>
          <subject>I.1.1 - Expressions and Their Representation</subject>
          <subject>I.6.4 - Model Validation and Analysis</subject>
          <subject>J.3 - LIFE AND MEDICAL SCIENCES</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Curve Fitting and Interpolation of Biological Data Under Uncertainties</article-title>
      </title-group>
      <contrib-group content-type="authors">
        <contrib contrib-type="author" corresp="yes">
          <name name-style="western">
            <surname>Markov</surname>
            <given-names>Svetoslav M.</given-names>
          </name>
          <email xlink:type="simple">smarkov@bgearn.bitnet</email>
          <xref ref-type="aff" rid="A1">1</xref>
        </contrib>
        <contrib contrib-type="author" corresp="no">
          <name name-style="western">
            <surname>Akyildiz</surname>
            <given-names>Y.</given-names>
          </name>
        </contrib>
      </contrib-group>
      <aff id="A1">
        <label>1</label>
        <addr-line content-type="verbatim">Research Group for Mathematical Modelling in Biology, Institute of Biophysics, Bulgarian Academy of Sciences, Sofia, Bulgaria</addr-line>
        <institution>Research Group for Mathematical Modelling in Biology, Institute of Biophysics, Bulgarian Academy of Sciences</institution>
        <addr-line content-type="city">Sofia</addr-line>
        <country>Bulgaria</country>
      </aff>
      <aff id="A2">
        <label>2</label>
        <addr-line content-type="verbatim">Mathematics Department, Bosphorus University, Istanbul, Turkey</addr-line>
        <institution>Mathematics Department, Bosphorus University</institution>
        <addr-line content-type="city">Istanbul</addr-line>
        <country>Turkey</country>
      </aff>
      <author-notes>
        <fn fn-type="corresp">
          <p>Corresponding author: Svetoslav M. Markov (<email xlink:type="simple">smarkov@bgearn.bitnet</email>).</p>
        </fn>
        <fn fn-type="edited-by">
          <p>Academic editor: </p>
        </fn>
      </author-notes>
      <pub-date pub-type="collection">
        <year>1996</year>
      </pub-date>
      <pub-date pub-type="epub">
        <day>28</day>
        <month>02</month>
        <year>1996</year>
      </pub-date>
      <volume>2</volume>
      <issue>2</issue>
      <fpage>59</fpage>
      <lpage>69</lpage>
      <uri content-type="arpha" xlink:href="http://openbiodiv.net/8A6D7B4B-AA4D-56E7-AB71-1FC7DA7E2796">8A6D7B4B-AA4D-56E7-AB71-1FC7DA7E2796</uri>
      <uri content-type="zenodo_dep_id" xlink:href="https://zenodo.org/record/6995194">6995194</uri>
      <permissions>
        <copyright-statement>Svetoslav M. Markov, Y. Akyildiz</copyright-statement>
        <license license-type="creative-commons-attribution" xlink:href="" xlink:type="simple">
          <license-p>This article is freely available under the J.UCS Open Content License.</license-p>
        </license>
      </permissions>
      <abstract>
        <label>Abstract</label>
        <p>This paper is devoted to the software implementation of two mathematical methods which are often used in biological applications: interpolation and curve fitting in the presence of uncertainties in the input data given in the form of intervals. The methods involve model functions linear in their parameters and are formulated by means of simple expressions in terms of interval arithmetic allowing the computation of verified bounds for the interpolating/approximating functions. The methods are demonstrated for certain classes of nonlinear modelling functions finding applications in biology. A case study involving enzyme-catalysed reaction is considered. The numerical results are performed in the computer algebra system Mathematica, which supports interval-arithmetic computations.</p>
      </abstract>
    </article-meta>
  </front>
</article>
